Discovering a way to put Parkin to work

Jacob Aguirre
Jacob Aguirre

Researchers now know that when a gene called Parkin is damaged, it can cause the familial form of Parkinson’s disease. Parkin’s role within brain cells is critical in making sure those cells produce energy and stay healthy.

What researchers need to know more about – and what biochemist Jacob Aguirre is investigating – is the chemical structure of Parkin. At the University of Western Ontario, Aguirre, a biochemist, uses a form of imaging called Nuclear Magnetic Resonance to study the structure of Parkin, right down to its foundation: Parkin’s atomic structure. Aguirre recently received a two-year, $30,000, graduate student grant from the Parkinson Canada Research Program to conduct his research.

“Our hope is that if we can get a firm understanding of Parkin’s atomic structure, that this can provide clues into its function in the cell and why these mutations are causing dysfunction for this protein, resulting in disease,” Aguirre says.

Pinpointing the chemical description of Parkin would help other researchers design new drugs that could either stimulate or block the protein’s function in brain cells.

Most researchers believe Parkin’s role is positive – that it turns on a recycling function to rid cells of damaged mitochondria, the energy producers within all cells. Aguirre, a PhD student, is focused on finding a way to activate Parkin when it is mutated, to restore that positive recycling function.

“We’re hoping that we can use a rational drug design method to come up with small molecules or drugs that might activate this protein,” Aguirre says. “This is a much more targeted form of drug discovery, rather than just serendipitous drug discovery.”

For Aguirre, the search for a drug that could address the fundamental causes of Parkinson’s disease is personal. Alzheimer’s disease and Parkinson’s disease affected his great-grandfather and his grandmother. He knows too well the devastating effects of these progressively debilitating illnesses.

“When you are exposed to it at a young age, it makes you really want to try to get involved in the research,” Aguirre says.

He hopes his research into Parkin’s atomic structure could not only led to new drugs but might be applied to new techniques like gene therapy.

“This has a lot of potential,” Aguirre says.

The search for new drug targets can sometimes be a frustrating quest, but he is motivated by his genuine excitement about the work and the thrill of discovery.

“It’s really an exhilarating thing to find something new,” Aguirre says. “To be able to do that in a field that I’m also personally affected by is just the cherry on the top.”

Watch our interview with Jacob Aguirre and read about other researchers recently funded by the Parkinson Canada Research Program.

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Mark your calendar and resolve to live your best in 2017

Kimberley Singian, RN, MSN

Every month, we have an opportunity for you to take charge of Parkinson’s and learn to live your best. Whether you are a person with Parkinson’s or sharing a home with someone living with the disease, why not make 2017 the year to learn more about how to live your best each day.

Topics cover understanding depression, medical marijuana, nutrition tips, and Parkinson’s disease and driving, among others. We’ve got a full year of podcasts (audio only) and webinars (visuals and audio), geared to topics that you won’t want to miss.

Give us one hour of your time each month and we’ll deliver insights from leading Canadian experts.  And you’ll be able to ask questions each session, too!

Mark your calendar now to make 2017 your year of learning!

February 14: Parkinson’s disease and the emotional rollercoaster; podcast with Sandie Jones, Parkinson Canada.

March 14: Medical Marijuana; webinar with Jonathan Zaid, founder and executive director of Canadians for Fair Access to Medical Marijuana (CFAMM). Zaid is recognized as a leading industry expert on medical cannabis, with a specialization on cost-coverage.

April 11:  World Parkinson’s Day – 200 years; podcast with Sandie Jones, Information and Referral Associate, Parkinson Canada.

May 11: Parkinson’s disease & nutrition; webinar with Nicole Shuckett, registered dietitian, from the Jeff and Diane Ross Movement Disorders Clinic and the ALS clinic at Sunnybrook Hospital.

June 13: Advanced stages of Parkinson’s; podcast with Sandie Jones, Parkinson Canada.

July 11: Physiotherapy and Parkinson’s; webinar with physiotherapists and founders Jan Goldstein and Rebecca Gruber of One Step Ahead Mobility.

August 8: Young onset Parkinson’s disease; podcast with Sandie Jones, Parkinson Canada.

September 12: Parkinson’s disease and driving; webinar with Beth Robertson, Occupational Therapist, McGill University Health Centre.

October 10: Build your PD health team; podcast with Sandie Jones, Parkinson Canada.

November 14: PD stress management; webinar with social worker Elaine Book, Center Coordinator and Clinic Social Worker for the Pacific Parkinson’s Research Centre, an NPF Center of Excellence, at the University of British Columbia, Vancouver, Canada.

December 12: Surviving the holidays; podcast with Sandie Jones, Parkinson Canada.
All of the one-hour sessions begin at noon (ET) and are delivered by experts on the topic of discussion. You will require access to a computer and you must register in advance at parkinson.ca/webinars for each individual session you plan to attend.

The January session, on PD and Depression, with Kimberley Singian, RN, MSN, and Dr. Zahra Goodarzi, was broadcast yesterday, and you can replay it in the coming days by going to parkinson.ca/webinars. All of the podcasts and webinars will be archived for playback a few days following their broadcast date.

Sandie Jones, an Information and Referral Associate at Parkinson Canada, will present each podcast, broadcast every second month in 2017, beginning in February. These sessions require only a telephone for access on the day of broadcast. You can choose to access the podcast using your computer.

Instructions to connect to podcasts only by phone:
Call 1(866)850-3418 or callers in the Greater Toronto Area may dial 416-915-8692. The participant code is 9415905.

Instructions to connect to podcasts only by computer
Log into the call using this link. Once you have opened the link, choose to enter as a guest. Turn on your speakers. Please send in any questions for Sandie Jones, in advance of the podcast, to education@parkinson.ca.

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A brighter future

Joyce Gordon, CEO, Parkinson Canada

When Parkinson’s disease comes into a person’s life and their home, it changes everything. We’ve been changing too. The recent union of six Parkinson’s organizations into one Parkinson Canada shows that we are taking the bold steps needed to grow our capacity to reach more people with Parkinson’s, effectively and efficiently. This is more important than ever given that the number of people with Parkinson’s is growing by more than 25 people each day.

It takes a community to live well with Parkinson’s, and you are an important part of the Parkinson’s extensive and global community. This past September marked  the fourth World Parkinson Congress in Portland, USA, where more than 4,400 researchers, clinicians, people with Parkinson’s and caregivers alike joined forces to share the latest information and advancements. We are inspired by the global Parkinson’s community. Parkinson Canada is more determined than ever to support you and all of our clients to tackle the challenges you face each day.

Parkinson Canada is the source of credible information for individuals living with Parkinson’s and their families. We are committed to expanding our offerings to you, using new technologies, as well as familiar vehicles, to share information that you and your loved ones can really use – accessible when, and how, you want it.  All of this is made possible through the ongoing generous support of valued donors.

In the coming year, the Canadian Guidelines on Parkinson’s disease will be updated to address gaps in care. More health care professionals – doctors, nurses, pharmacists and various therapists – will have access to these guidelines, and additional professional education, helping to ensure that you and your loved ones receive optimal care.

With continued donor support, we will plant more seeds for exploration and collaboration. The impact of the Parkinson Canada Research Program goes beyond an investment in discovery-stage research. Canadian scientists gain access to new funding from other sources, based on proven early results from their Parkinson Canada funded projects. This leads to new treatments, greater understanding and improved quality of life. Above all, we know that for you and others, a cure can’t wait.

We’ll talk with you and listen to you, and be your voice in the political arena, to make your life better. We continue to blaze the trail and join forces with others to increase our influence on policymakers and elected representatives. Parkinson Canada and our nationwide network of Ambassadors – people just like you from each province – will speak out for all Canadians living with Parkinson’s.

Connect with us on the telephone, in person out in the community and online. Simply put, we share a unity of purpose to expand our reach and increase our effectiveness in all that we do. That’s our commitment to you.

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Understanding deep brain stimulation

Dr. Reina Isayama
Dr. Reina Isayama

Deep brain stimulation is a surgical intervention used to treat the tremors, rigidity, stiffness and slow movements that people with Parkinson’s disease experience. Although researchers know the technique works by changing abnormal electrical signals deep in the brain’s basal ganglia, they don’t understand the mechanisms involved.

Dr. Reina Isayama is exploring the basal ganglia’s relationship with the cerebral cortex, on the surface of the brain. She is trying to determine how the two areas of the brain interact and why deep brain stimulation (DBS) also affects the circuitry in that cerebral cortex, which, in people with Parkinson’s, has a particularly abnormal signalling pattern.

“We know that DBS works for Parkinson’s motor symptoms, but we still don’t know how it works,” says Isayama.

Isayama, a neurologist and Clinical Fellow at Toronto Western Hospital’s Movement Disorders Clinic, will use electroencephalograms (EEGs) to record the surface of the brain, where cells are activated and are communicating following DBS. She’ll study their relationship with the clinical benefits of DBS. Her two-year, $100,000 Clinical Research Fellowship is funded by the Parkinson Canada Research Program.

Isayama hopes by understanding how DBS works on the brain’s cortex, she will be able to suggest better adjustments to the technique, such as delivering the electrical stimulus to the brain at higher or lower frequencies, to shorten the time necessary to improve the symptoms. She may also identify areas on the surface of the brain that can be treated with other brain stimulation techniques in future.

“If we understand the influence of DBS to the cortex, we may be able to develop some less invasive techniques,” she says.

During her residency training in her native Japan, Isayama’s first research project involved Parkinson’s disease. She was struck by the “willingness and kindness” of the patients she worked with.

“I always hoped that I would be involved in research studies related to movement disorders and Parkinson’s disease,” she says.

Isayama believes it’s important to conduct research as well as to treat people with Parkinson’s in a clinical setting, so that she can apply her knowledge to make a difference in her patients’ lives.

“I’d like to be a person who can apply research results in a real clinical setting,” she says.

Watch our interview with Dr. Isayama and read about other researchers recently funded by the Parkinson Canada Research Program.

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Congratulations to our young philanthropist

Jenna Sigurdson, left, with her parents Karren and Blair at Manitoba Philanthropy Awards luncheon.
Jenna Sigurdson, left, with her parents Karren and Blair at Manitoba Philanthropy Awards luncheon.

It was with great pride that Jenna Sigurdson’s parents, Karren and Blair, and her grandfather watched as she received the Outstanding Youth in Philanthropy Award, Under 15, during the 2016 Manitoba Philanthropy Awards luncheon in Winnipeg last month.

Red River Cooperative senior staff, her school principal and two representatives of Parkinson Canada’s Manitoba office were also in attendance to honour Jenna. She has raised more than $50,000 for Parkinson Canada and she has increased awareness of the disease, which affects more than 6,500 people in the province and more than 100,000 across the country.

Five years ago, at the age of 10, Jenna learned that her Dad had young-onset Parkinson’s disease. Jenna decided to fundraise for the cause, to help those living with the disease and to fund research into better treatments and an eventual cure.  She began by knocking on more than 2,000 doors in her community.

At age 11, Jenna combined her love of reading with the Parkinson’s cause and designed a signature bookmark and founded “Jenna’s Toonies for Tulips,” selling the bookmarks each year, through school campaigns and in partnership with local retailers. They are available for a minimum donation of $2 each.

Jenna also organizes a school assembly each April during Parkinson Awareness Month with a special speaker. Her various awareness and fundraising campaigns have brought Parkinson’s disease an enormous amount of media attention, increasing public awareness in the province.

“We are very grateful for all that Jenna has accomplished on behalf of people living with Parkinson’s in our community,” says Lorri Apps, Parkinson Canada’s Managing Director, Manitoba. “She is also an inspiration to others and an incredible example of the positive influence that young people can have on us all.”

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