Benefits and risks of participating in a clinical trial

Benefits

Clinical trials that are well-designed and well-executed offer excellent opportunities for eligible participants to:

  • Play an active role in their own health care.
  • Obtain referrals to a study site.
  • Engage care partners as companions in care.
  • Gain access to new research treatments before they are widely available.
  • Obtain expert medical, sometimes multidisciplinary, care at leading health care facilities during the trial.
  • Help others by contributing to medical research.
  • Enhance personal knowledge of a medical condition.

Risks

There are risks to clinical trials.

  • Depending on the study design, there may be no guarantee that the participant will receive the active ingredient.
  • There may be unpleasant, serious or even life-threatening side effects to experimental treatment.
  • The experimental treatment may not be effective for the participant.
  • The research may require collection of data, for example, genetic information, that could potentially cause psychological or informational harm.
  • The research criteria may require lifestyle modifications, for example, dietary changes.
  • The protocol may require more of the participant’s time and attention than would a non-protocol treatment, including trips to the study site, more treatments, hospital stays or complex dosage requirements.
  • The experimental drug may not be approved by Health Canada and, if approved, may not be covered under provincial drug formularies.

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